| | | | HEURE | STADE | HOTE | SCORE | VISITEUR | RETRANSMIS PAR | | | | Jeudi 19 Août 2021 | | | | 15:00 |  |  | Chakhtior Karagandy |
| 1 - 2 | | Maccabi Tel Aviv |  |
| | | 18:00 | |  | Rakow Czestochowa |
| 1 - 0 | | La Gantoise |  |
| | | 18:00 | |  | KuPS Kuopio |
| 0 - 4 | | Union Berlin |  |
| | | 18:00 |  |  | Qarabag FK |
| 1 - 0 | | Aberdeen |  |
| | | 18:00 |  |  | Flora Tallinn |
| 4 - 2 | | Shamrock Rovers |  |
| | | 19:00 |  |  | Hapoel Beer Sheva |
| 0 - 0 | | Anorthosis Famagouste |  |
| | | 19:00 | |  | Neftchi Bakou |
| 3 - 3 | | Maccabi Haifa |  |
| | | 19:00 | |  | Viktoria Plzen |
| 2 - 0 | | CSKA Sofia |  |
| | | 19:00 | |  | Riga FC |
| 1 - 1 | | Lincoln Red Imps |  |
| | | 19:00 |  |  | LASK Linz |
| 1 - 1 | | St. Johnstone |  |
| | | 19:00 | |  | Zalgiris Vilnius |
| 2 - 2 | | FK Bodo Glimt |  |
| | | 19:30 | |  | Fola Esch |
| 1 - 4 | | Kairat Almaty |  |
| | | 19:30 |  |  | Trabzonspor |
| 1 - 2 | | AS Rome |  |
| | | 19:30 |  |  | FC Bâle |
| 3 - 1 | | Hammarby IF |  |
| | | 20:00 |  |  | Sivasspor |
| 1 - 2 | | FC Copenhague |  |
| | | 20:00 |  |  | Rennes |
| 2 - 0 | | Rosenborg |  |
| | | 20:00 | |  | Anderlecht |
| 3 - 3 | | Vitesse Arnhem |  |
| | | 20:00 |  |  | PAOK Salonique |
| 1 - 1 | | HNK Rijeka |  |
| | | 20:00 |  |  | FK Jablonec |
| 5 - 1 | | Zilina |  |
| | | 20:00 |  |  | Feyenoord Rotterdam |
| 5 - 0 | | Elfsborg Boras |  |
| | | 20:30 | |  | Paços de Ferreira |
| 1 - 0 | | Tottenham |  |
| | | 22:30 | |  | Santa Clara |
| 2 - 1 | | Partizan Belgrade |  |
| | | | | Jeudi 26 Août 2021 | | | | 16:00 |  | | Kairat Almaty (Q) |
| 3 - 1 | | Fola Esch | |
| | | 18:00 |  | | Lincoln Red Imps (Q) |
| 3 - 1 | | Riga FC | |
| | | 18:00 |  | | FK Bodo Glimt (Q) |
| 1 - 0 | | Zalgiris Vilnius | |
| | | 18:00 | | | Zilina |
| 0 - 3 | | FK Jablonec (Q) | |
| | | 18:45 | | | Elfsborg Boras |
| 3 - 1 | | Feyenoord Rotterdam (Q) | |
| | | 19:00 |  | | Anorthosis Famagouste (Q) |
| 3 - 1 | | Hapoel Beer Sheva | |
| | | 19:00 |  | | Maccabi Haifa (Q) |
| 4 - 0 | | Neftchi Bakou | |
| | | 19:00 |  | | CSKA Sofia (Q) |
| 3 - 0 | | Viktoria Plzen | |
| | | 19:00 |  | | AS Rome (Q) |
| 3 - 0 | | Trabzonspor | |
| | | 19:00 | | | Hammarby IF |
| 3 - 1 ap. (3 tab 4) | | FC Bâle (Q) | |
| | | 19:00 |  | | FC Copenhague (Q) |
| 5 - 0 | | Sivasspor | |
| | | 19:00 |  | | Rosenborg |
| 1 - 3 | | Rennes (Q) | |
| | | 19:00 |  | | Vitesse Arnhem (Q) |
| 2 - 1 | | Anderlecht | |
| | | 19:30 |  | | Maccabi Tel Aviv (Q) |
| 2 - 0 | | Chakhtior Karagandy | |
| | | 20:00 |  | | La Gantoise (Q) |
| 3 - 0 | | Rakow Czestochowa | |
| | | 20:00 | | | St. Johnstone |
| 0 - 2 | | LASK Linz (Q) | |
| | | 20:00 |  | | HNK Rijeka |
| 0 - 2 | | PAOK Salonique (Q) | |
| | | 20:15 |  | | Union Berlin (Q) |
| 0 - 0 | | KuPS Kuopio | |
| | | 20:45 | | | Aberdeen |
| 1 - 3 | | Qarabag FK (Q) | |
| | | 20:45 |  | | Tottenham (Q) |
| 3 - 0 | | Paços de Ferreira | |
| | | 21:00 | | | Shamrock Rovers |
| 0 - 1 | | Flora Tallinn (Q) | |
| | | 21:00 |  | | Partizan Belgrade (Q) |
| 2 - 0 | | Santa Clara | |
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