| | | | HEURE | STADE | HOTE | SCORE | VISITEUR | RETRANSMIS PAR | | | | Mardi 17 Août 2021 | | | | 21:00 |  |  | Etoile rouge de Belgrade |
| 4 - 0 | | CFR Cluj |  |
| | | | | Mercredi 18 Août 2021 | | | | 20:45 |  |  | Celtic Glasgow |
| 2 - 0 | | AZ Alkmaar |  |
| | | | | Jeudi 19 Août 2021 | | | | 19:00 |  |  | Randers FC |
| 1 - 1 | | Galatasaray |  |
| | | 19:00 |  |  | Slavia Prague |
| 2 - 2 | | Legia Varsovie |  |
| | | 19:00 |  |  | Omonia Nicosie |
| 4 - 2 | | Royal Antwerp |  |
| | | 20:00 |  |  | NK Mura |
| 1 - 3 | | Sturm Graz |  |
| | | 20:45 |  |  | Fenerbahçe |
| 1 - 0 | | HJK Helsinki |  |
| | | 21:00 |  |  | Rapid Vienne |
| 3 - 0 | | Zorya Luhansk |  |
| | | 21:00 |  |  | Olimpiakos Le Pirée |
| 3 - 0 | | Slovan Bratislava |  |
| | | 21:00 |  |  | Glasgow Rangers |
| 1 - 0 | | FC Alashkert |  |
| | | | | Jeudi 26 Août 2021 | | | | 18:00 |  | | Galatasaray (Q) |
| 2 - 1 | | Randers FC | |
| | | 18:00 |  | | HJK Helsinki |
| 2 - 5 | | Fenerbahçe (Q) | |
| | | 18:00 |  | | FC Alashkert |
| 0 - 0 | | Glasgow Rangers (Q) | |
| | | 18:30 |  | | Zorya Luhansk |
| 2 - 3 | | Rapid Vienne (Q) | |
| | | 20:15 |  | | AZ Alkmaar |
| 2 - 1 | | Celtic Glasgow (Q) | |
| | | 20:30 |  | | CFR Cluj |
| 1 - 2 | | Etoile rouge de Belgrade (Q) | |
| | | 20:45 |  | | Slovan Bratislava |
| 2 - 2 | | Olimpiakos Le Pirée (Q) | |
| | | 21:00 |  | | Sturm Graz (Q) |
| 2 - 0 | | NK Mura | |
| | | 21:00 |  | | Legia Varsovie (Q) |
| 2 - 1 | | Slavia Prague | |
| | | 21:00 |  | | Royal Antwerp (Q) |
| 2 - 0 ap. (3 tab 2) | | Omonia Nicosie | |
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